CO₂ Biomanufacturing

Using the original technology from Professor Wei Huang's team at Oxford University, a new generation of green biomanufacturing platform is constructed with photovoltaic-driven artificial photosynthesis and bacterial bionanoreactors at its core. This platform directly synthesizes high-value products from CO₂, achieving integrated solutions for carbon-negative production, clean energy, and bio-based materials.

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Core Technology

1. Artificial Photosynthesis System (Nature Communications, 2023)

  • Using rhodopsin (GR) as a light-harvesting system to break through the efficiency bottleneck of traditional chlorophyll photosynthesis
  • Equipping with a canthaxanthin (CAN) light-capturing antenna to greatly improve the efficiency of the proton pump
  • Importing the MtrCAB transmembrane electron transfer pathway to achieve efficient electron supply from the electrode to the cell
  • Overexpressing carbonic anhydrase to enhance CO₂ absorption and conversion
  • Achieving dual drive of light and electricity, with CO₂ as the sole carbon source, to directly synthesize biomass and products
  • Reaching a conversion efficiency 10 times higher than that of natural photosynthesis

2. Bionanoreactor (PNAS, 2024)

  • Constructing an efficient reactor in the 20-30 nm periplasmic space using electroactive Shewanella MR-1 as the substrate
  • Achieving self-assembly of FeS nanoparticles to enhance electron transfer efficiency by more than 2 times
  • Using an RGO-modified electrode to enhance interface electronic conductivity and triple the hydrogen production rate
  • Driving the proton pump system with light to further increase the yield by 35.6% under illumination
  • Overexpressing [FeFe]-hydrogenase to achieve a hydrogen production rate 10 times higher than that of the wild type

  • Reaching a Faraday efficiency of up to 80%

 

Products and Solutions

Product direction

Explanation

Single-cell protein

Production of bacterial protein using CO₂ as carbon source and photovoltaic energy for animal feed

Biodegradable plastics (PHA)

By utilizing R. eutropha to redirect carbon flux towards biomass, PHA can be further synthesized

Optoelectronic slot system

Integrated reactor, including solar panel, voltage regulator, carbon paper electrode, proton exchange membrane, used for laboratory or pilot scale CO₂ conversion

Engineering bacterial strains and gene modules

Provide genetic components for customized carbon sequestration bacterial strain construction

 

Technical Advantage

  • True zero carbon path: using CO₂ as raw material, not relying on grain-based carbon sources such as sugar and starch
  • Revolutionary breakthrough in efficiency: dual engines of rhodopsin light capture and bio-nano reactor
  • Optoelectronic collaborative drive: solar energy + renewable electricity, clean and sustainable
  • Mild and safe: normal temperature and pressure, no high temperatures or pressures, no dangerous catalysts
  • Scalability: one platform can produce various products such as hydrogen, protein, materials, chemicals, etc.
  • Top tier research support: results published in top international journals such as Nature and PNAS

Technological achievements and honors

  1. Selected by Nature as one of the top 25 high-impact life science papers of 2023: "Engineering artificial photosynthesis based on rhodopsin for CO₂ fixation." Nature Communications, 2023.
  2. Engineering bionanoreactor in bacteria for efficient hydrogen production. PNAS, 2024.
  3. International patents granted
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